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Recent publication and presentation at the American Psychiatric Association Annual Meeting demonstrated numerous benefits of Ashwagandha on stress, cognition, energy, depression, memory, and thyroid support. Studies reported significant improvement in memory, cognition, and mood in subjects who were taking Ashwagandha vs placebo. Full efficacy for depression was demonstrated after 3-4 weeks of administration and improvement in cognition were demonstrated within 2 weeks. Most common side effect is fatigue and gastrointestinal upset, which can be remedied by taking it with food. Most side effects are transient and mild. Ashwagandha is not recommended in pregnancy and lactation.


J Diet Suppl. 2017 Nov 2;14(6):599-612. doi: 10.1080/19390211.2017.1284970. Epub 2017 Feb 21.

Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.

Choudhary D1Bhattacharyya S2Bose S2.

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Cognitive decline is often associated with the aging process. Ashwagandha (Withania somnifera (L.) Dunal) has long been used in the traditional Ayurvedic system of medicine to enhance memory and improve cognition.


This pilot study was designed to evaluate the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) in improving memory and cognitive functioning in adults with mild cognitive impairment (MCI).


A prospective, randomized, double-blind, placebo-controlled study was conducted in 50 adults. Subjects were treated with either ashwagandha-root extract (300 mg twice daily) or placebo for eight weeks.


After eight weeks of study, the ashwagandha treatment group demonstrated significant improvements compared with the placebo group in both immediate and general memory, as evidenced by Wechsler Memory Scale III subtest scores for logical memory I (p = 0.007), verbal paired associates I (p = 0.042), faces I (p = 0.020), family pictures I (p = 0.006), logical memory II (p = 0.006), verbal paired associates II (p = 0.031), faces II (p = 0.014), and family pictures II (p = 0.006). The treatment group also demonstrated significantly greater improvement in executive function, sustained attention, and information-processing speed as indicated by scores on the Eriksen Flanker task (p = 0.002), Wisconsin Card Sort test (p = 0.014), Trail-Making test part A (p = 0.006), and the Mackworth Clock test (p = 0.009).


Ashwagandha may be effective in enhancing both immediate and general memory in people with MCI as well as improving executive function, attention, and information processing speed.


Withania somnifera (L.) Dunal; ashwagandha; cognition; efficacy; memory; safety



DOI: 10.1080/19390211.2017.1284970



Gut health has been linked to a wide variety of mood and cognitive troubles. Intestinal bacteria secrete a large number of signaling chemicals that control immunity, inflammation, stress response, and mood. Target GBX contains probiotic blend specifically designed to influence gut-brain axis and demonstrated proven support for positive mood.

Neurotherapeutics. 2018 Jan;15(1):36-59. doi: 10.1007/s13311-017-0585-0.

Anxiety, Depression, and the Microbiome: A Role for Gut Peptides.

Lach G1Schellekens H1,2,3Dinan TG1,4Cryan JF5,6.

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The complex bidirectional communication between the gut and the brain is finely orchestrated by different systems, including the endocrine, immune, autonomic, and enteric nervous systems. Moreover, increasing evidence supports the role of the microbiome and microbiota-derived molecules in regulating such interactions; however, the mechanisms underpinning such effects are only beginning to be resolved. Microbiota-gut peptide interactions are poised to be of great significance in the regulation of gut-brain signaling. Given the emerging role of the gut-brain axis in a variety of brain disorders, such as anxiety and depression, it is important to understand the contribution of bidirectional interactions between peptide hormones released from the gut and intestinal bacteria in the context of this axis. Indeed, the gastrointestinal tract is the largest endocrine organ in mammals, secreting dozens of different signaling molecules, including peptides. Gut peptides in the systemic circulation can bind cognate receptors on immune cells and vagus nerve terminals thereby enabling indirect gut-brain communication. Gut peptide concentrations are not only modulated by enteric microbiota signals, but also vary according to the composition of the intestinal microbiota. In this review, we will discuss the gut microbiota as a regulator of anxiety and depression, and explore the role of gut-derived peptides as signaling molecules in microbiome-gut-brain communication. Here, we summarize the potential interactions of the microbiota with gut hormones and endocrine peptides, including neuropeptide Y, peptide YY, pancreatic polypeptide, cholecystokinin, glucagon-like peptide, corticotropin-releasing factor, oxytocin, and ghrelin in microbiome-to-brain signaling. Together, gut peptides are important regulators of microbiota-gut-brain signaling in health and stress-related psychiatric illnesses.

PMID: 29134359






Maca naturally supports normal hormone balance, menstrual and reproductive health from your teens through your reproductive years. It has been proven to support normal hormone balance, hormal menstrual cycles, symptoms related to monthly menstruation, healthy energy levels, balanced mood, normal reproductive health, clear skin, hair and nails, improved sexual functioning and libido. It has also been proven to counteract sexual side effects of antidepressants. Women report relief as fast as 1-2 cycles. Maca is not recommended in women with reproductive cancers, fibroids, or pregnant or lactating women.

A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women.

Dording CM1Schettler PJ2Dalton ED1Parkin SR1Walker RS1Fehling KB1Fava M1Mischoulon D1.

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We sought to demonstrate that maca root may be an effective treatment for antidepressant-induced sexual dysfunction (AISD) in women.


We conducted a 12-week, double-blind, placebo-controlled trial of maca root (3.0 g/day) in 45 female outpatients (mean age of 41.5 ± 12.5 years) with SSRI/SNRI-induced sexual dysfunction whose depression remitted. Endpoints were improvement in sexualfunctioning as per the Arizona Sexual Experience Scale (ASEX) and the Massachusetts General Hospital Sexual Function Questionnaire (MGH-SFQ).


45 of 57 consented females were randomized, and 42 (30 premenopausal and 12 postmenopausal women) were eligible for a modified intent-to-treat analysis based on having had at least one postmedication visit. Remission rates by the end of treatment were higher for the maca than the placebo group, based on attainment of an ASEX total score ≤ 10 (9.5% for maca versus 4.8% for placebo), attaining an MGH-SFQ score ≤ 12 (30.0% for maca versus 20.0% for placebo) and reaching an MGH-SFQ score ≤ 8 (9.5% for maca versus 5.0% for placebo). Higher remission rates for the maca versus placebo group were associated with postmenopausal status. Maca was well tolerated.


Maca root may alleviate SSRI-induced sexual dysfunction in postmenopausal women. This trial is registered with NCT00568126.

PMID: 25954318

PMCID: PMC4411442

DOI: 10.1155/2015/949036